Stimulus induced modulation of low frequency fluctuations in BOLD fMRI of the rat
نویسندگان
چکیده
Introduction: Low frequency fluctuations (LFFs) in T2*-weighted MR images have been observed in humans as well as rats [1, 2, 3]. Although previous studies explore the effect of task/stimulation on functional connectivity (FC) maps created from LFFs (e.g. [4]), the effect of stimulation on LFFs has not been explored. In this study, the amplitude of the LFFs before and during continuous somatosensory stimulation was examined. Stimulation reduced power of LFFs in the corresponding area in the primary somatosensory cortex (SI) as well as the contralateral cortical region ‘functionally connected’ with the stimulated cortex. This finding suggests that LFFs are altered in response to neural activity.
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